Serums
Exo-PDRN Prismatic+
Inspired by polynucleotide treatments, Exo-PDRN Prismatic+ has been expertly designed to deliver a multi-dimensional approach to visible skin health, boosting the skin’s natural rejuvenation by +50%[1].Powered by intelligent prismatic PDRN, with a stable tetrahedral structure that mimics an arrow’s aerodynamic form, to allow for optimal penetration. Prismatic PDRN delivers 2x better skin absorption and 60% deeper skin penetration than traditional PDRN[4], to support skin recovery. The result? Next-generation rejuvenation for visibly enhanced luminosity and lasting resilience.A highly concentrated triple exosome complex, featuring up to 151 billion exosomes per bottle, and our breakthrough GF MiniProteinTM visibly restores by supporting the skin’s natural signalling processes that facilitate skin resilience and reinforce the skin barrier. An ATP Precursor supports the skin’s natural processes involved in visible rejuvenation, for a smoother, more revitalised complexion. Key Benefits Visible Skin Rejuvenation Scientifically proven to boost the skin’s natural rejuvenation by over 50%. [1] Refined Tone & Texture Supports visibly smoother skin with improved tone and texture. Optimal Skin Recovery Support Designed to support the skin’s natural recovery processes, making it ideal for daily use and alongside professional treatments. Restored Vitality & Luminosity Clinically proven to improve the look of skin luminosity and vitality in 7 days. [2] Visibly Calm, Resilient-Looking Skin Clinically proven to improve skin barrier function in 7 days. [2] Proven Results Before After Before After +50% boost in natural skin rejuvenation [1] 7 days to improved skin barrier function [2] 7 days to improved skin tone [2] 7 days to improved skin luminosity [2] 7 days to visibly improved skin volume [2] 14 days to visibly improved wrinkles [2] 14 days to improved firmness [2] 100% agree this is the perfect post-procedure partner for their in-clinic PDRN treatment [3] 98% agree the results continue to get better with time [3] [1] Proven via ex vivo study measuring Ki67 protein marker for cell proliferation vs. untreated control after 24 hours. [2] Proven via independent clinical study on Exo-PDRN Prismatic+ on 60 volunteers over 8 weeks. [3] Proven via independent consumer study conducted over 4 weeks on 52 participants who had received injectable polynucleotide treatments within a week of the study. [4] Proven via in vitro skin penetration study versus salmon and rose PDRN benchmarks. | Please Note: Product packaging shown may be different to the product received due to regional variations. How to Use First-time use If you're new to Exo-PDRN Primastic+, we recommend a patch test at least 24 hours before first use. Learn how to patch test here . How To Use After cleansing in the morning and evening, apply 1-2 pumps of Exo-PDRN Prismatic+ evenly across the face, neck & décolletage. Use light upward strokes and allow to fully absorb. Uses per bottle 80 Guide to Layering Step 1: Cleanse Surface Radiance Cleanse™ Select a Size Full Size (150ml) Full Size (150ml) Travel Size (40ml) Add to Bag £25 Step 2: Target Exo-PDRN Prismatic+ Full size (30ml) Add to Bag £79 Step 3: Brighten C-Tetra® Advanced Full Size (30ml) Add to Bag £72 Step 5: Moisturise Advanced Pro-Collagen+ Peptide Cream Select a Size Full size (50ml) Full size (50ml) Travel size (12.5ml) Refill (50ml) Add to Bag £82 Step 5: Protect Advanced Day Ultimate Protect™ Full Size (50ml) Add to Bag £59 Key Ingredients Prismatic PDRN A pioneering form of vegan (certified by The Vegan Society to be formulated without animal-derived ingredients or by-products) PDRN with a stable tetrahedral structure for 100% better skin absorption than traditional PDRN. [4] Composed of DNA particles that penetrate 61% deeper than traditional PDRN [4] to support skin recovery, help soothe visible irritation and reveal smoother, more youthful-looking skin. Triple Exosome Complex Designed to support natural skin signalling processes, resilience and recovery, helping to strengthen the skin barrier and promote a healthier, more radiant-looking complexion. GF MiniProtein TM Visibly improves the appearance of skin structure over time by helping to boost skin’s collagen, elastin & hyaluronic acid levels. ATP Precursor An energy-carrying molecule that helps optimise the natural processes involved in visible skin rejuvenation. GF MiniProtein TM Visibly improves the appearance of skin structure over time by helping to boost skin’s collagen, elastin & hyaluronic acid levels. ATP Precursor An energy-carrying molecule that helps optimise the natural processes involved in visible skin rejuvenation. See More View all Clinically proven Fragrance-free Dermatologically tested Proven gentle formula Certified by the vegan society Experts Recommended "Exo-PDRN Prismatic+ reflects our belief that visible rejuvenation comes from supporting the skin’s inherent biology. We engineered a formula that works with the natural processes skin relies on to recover and function at its best. By addressing Recover, Restore and Recharge together, we help create the optimal conditions for skin to look healthier and visibly rejuvenated." DANIEL ISAACS Chief Product Officer & Founding Partner of Medik8 Can I use Exo-PDRN Prismatic+ with Crystal Retinal? Absolutely. Exo-PDRN Prismatic+ and Crystal Retinal make an ideal age-defying duo. Crystal Retinal is our iconic nightly vitamin A serum which targets all signs of skin ageing; wrinkles, firmness, elasticity, dark spots, skin texture, and more. Exo-PDRN Prismatic+ is a twice daily lightweight serum which supports long-term skin rejuvenation and recovery. We recommend layering thinnest to thickest, where Crystal Retinal would be applied after Exo-PDRN Prismatic+. What does skin health mean to Medik8? At Medik8, true skin health means supporting the skin’s inherent biology. It is about building a resilient skin barrier and providing the skin with support to help it function at its peak. When your skin is healthy, visible vitality and radiance naturally follows. Our Exo-PDRN Prismatic+ is the ultimate expression of this philosophy, utilising a 'Rejuvenation Blueprint' to recover, restore, and recharge the skin. Through our independent clinical trials 'overall skin quality and healthy appearance' were graded. While one end of the spectrum represented skin that looks dull, lax, or unhealthy, our ultimate goal is to guide the skin all the way to the gold standard on the other end of the spectrum. In our trials, this peak profile is officially defined as 'extremely healthy, vibrant, and radiant in appearance.' The result of our clinical trials using Exo-PDRN Prismatic+ was the the product was clinically proven to improve the appearance of skin health in 7 days. [2] Is it suitable for sensitive skin? Yes. Exo-PDRN Prismatic+ is designed to be gentle and suitable for sensitive skin. Can I use it with makeup? Yes. Exo-PDRN Prismatic+ has been tested to layer seamlessly under makeup, making it ideal for everyday use. Why are you not using spicules like other exosome serums on the market? Spicules work by creating micro-channels through controlled micro-trauma. We chose not to include spicules as that can be unnecessarily harsh on post-treatment skin. Instead, Exo-PDRN Prismatic+ uses a carefully engineered combination of advanced ingredients to deliver results in a gentler, more comfortable way, without placing unnecessary stress on the skin. Can I use Exo-PDRN Prismatic+ with Liquid Peptides Advanced MP? Absolutely. Exo-PDRN Prismatic+ and Liquid Peptides Advanced MP make an ideal age-defying duo. Use Liquid Peptides Advanced MP to target expression lines and build visible wrinkle reduction and Exo-PDRN Prismatic+ to support long-term skin rejuvenation, resilience and recovery. Does the 'GF' in GF MiniProtein™ (found in Liquid Peptides Advanced MP, Advanced Pro-Collagen+ Peptide Cream, and Exo-PDRN Prismatic+) stand for Growth Factor? Yes, the 'GF' on our packaging stands for Growth Factor MiniProtein™, a next-generation form of growth factor in skincare. Its small molecular size makes it more advanced than traditional options like TGF, EGF, and IGF, allowing it to unlock previously untapped cosmetic effectiveness within the skin's anti-ageing pathways. Can I use Exo-PDRN Prismatic+ with exfoliating acids? Yes. Exo-PDRN Prismatic+ can be applied after exfoliating acids. We recommend following with a moisturiser to help support the skin barrier and minimise the risk of any dryness. Is Exo-PDRN Prismatic+ suitable for dry skin? Yes. The formula contains hydrating and soothing ingredients, making it suitable for dry skin. Due to its water-light texture, we recommend following with a moisturiser for optimal comfort and results. Is Exo-PDRN Prismatic+ suitable for oily skin? Yes. Exo-PDRN Prismatic+ is oil-free and suitable for oily skin types. It delivers an instant healthy glow without leaving skin looking shiny. Can I use Exo-PDRN Prismatic+ with C-Tetra Advanced? Absolutely. Exo-PDRN Prismatic+ and C-Tetra Advanced make an ideal duo to help improve the skin’s natural recovery mechanisms. Use C-Tetra Advanced to defend against premature skin ageing and achieve accelerated visible skin brightening, and Exo-PDRN Prismatic+ to support long-term skin rejuvenation, resilience and recovery. Should I choose Exo-PDRN or Liquid Peptides Advanced MP? Both formulas are powerhouses and although there are slight overlaps, they focus on different skin goals. They also complement each other perfectly and can be used together in the same routine. Choose Liquid Peptides Advanced MP if your main goal is line-smoothing. It uses dual MiniProteins™ supported by a concentrated peptide complex to specifically target expression lines and build visible wrinkle reduction over time. Choose Exo-PDRN Prismatic+ if your skin needs comprehensive rejuvenation and vitality. It focuses on recovery and uses next generation PDRN technology and exosomes to support the skin barrier and restore a healthy glow. If you decide to incorporate both into your routine, we recommend layering from thinnest to thickest consistency. In this case, apply Exo-PDRN Prismatic+ first, followed by Liquid Peptides Advanced MP, both morning and evening. Can I use Exo-PDRN Prismatic+ with exfoliating acids? Yes. Exo-PDRN Prismatic+ can be applied after exfoliating acids. We recommend following with a moisturiser to help support the skin barrier and minimise the risk of any dryness. Is Exo-PDRN Prismatic+ suitable for dry skin? Yes. The formula contains hydrating and soothing ingredients, making it suitable for dry skin. Due to its water-light texture, we recommend following with a moisturiser for optimal comfort and results. Is Exo-PDRN Prismatic+ suitable for oily skin? Yes. Exo-PDRN Prismatic+ is oil-free and suitable for oily skin types. It delivers an instant healthy glow without leaving skin looking shiny. Why are you not using spicules like other exosome serums on the market? Spicules work by creating micro-channels through controlled micro-trauma. We chose not to include spicules as that can be unnecessarily harsh on post-treatment skin. Instead, Exo-PDRN Prismatic+ uses a carefully engineered combination of advanced ingredients to deliver results in a gentler, more comfortable way, without placing unnecessary stress on the skin. Can I use Exo-PDRN Prismatic+ with Liquid Peptides Advanced MP? Absolutely. Exo-PDRN Prismatic+ and Liquid Peptides Advanced MP make an ideal age-defying duo. Use Liquid Peptides Advanced MP to target expression lines and build visible wrinkle reduction and Exo-PDRN Prismatic+ to support long-term skin rejuvenation, resilience and recovery. Can I use Exo-PDRN Prismatic+ with C-Tetra Advanced? Absolutely. Exo-PDRN Prismatic+ and C-Tetra Advanced make an ideal duo to help improve the skin’s natural recovery mechanisms. Use C-Tetra Advanced to defend against premature skin ageing and achieve accelerated visible skin brightening, and Exo-PDRN Prismatic+ to support long-term skin rejuvenation, resilience and recovery. Should I choose Exo-PDRN or Liquid Peptides Advanced MP? Both formulas are powerhouses and although there are slight overlaps, they focus on different skin goals. They also complement each other perfectly and can be used together in the same routine. Choose Liquid Peptides Advanced MP if your main goal is line-smoothing. It uses dual MiniProteins™ supported by a concentrated peptide complex to specifically target expression lines and build visible wrinkle reduction over time. Choose Exo-PDRN Prismatic+ if your skin needs comprehensive rejuvenation and vitality. It focuses on recovery and uses next generation PDRN technology and exosomes to support the skin barrier and restore a healthy glow. If you decide to incorporate both into your routine, we recommend layering from thinnest to thickest consistency. In this case, apply Exo-PDRN Prismatic+ first, followed by Liquid Peptides Advanced MP, both morning and evening. Help Products About Resources Kathy A. 🇬🇧 Verified Buyer 14/06/26 Erin G. 🇺🇸 Verified Buyer 16/05/26 Rafy 🇬🇧 Verified Buyer 14/05/26 Olena 🇬🇧 Verified Buyer 10/05/26 Natasha K. 🇬🇧 Verified Buyer 10/05/26 Natrah 🇬🇧 Verified Buyer 10/05/26
