Peptides 5% Smoothing Booster

A dual-peptide booster to firm and smooth.Walk through the peptide category and you'll see synthetics almost without exception. Ours are different: one fermented from yeast, the other from peas, both COSMOS certified. That's genuinely rare in peptide territory, which translates to real anti-aging results inside a fully natural formula.The pairing here is Hexapeptide-11 and Pea Peptide, and they handle different parts of the same job. Hexapeptide-11 acts as the messenger, telling your fibroblasts to dial up production of collagen and elastin. Pea Peptide brings the raw materials, especially lysine. It's an essential amino acid you can't produce internally, and it's vital for locking collagen molecules into resilient, well-formed fibers. The outcome: skin that feels firmer and bouncier, with a visibly smoother finish.A small piece of botany trivia: peas hold one of the most well-rounded amino acid profiles among plant proteins, containing every one of the 22 amino acids. That richness translates to film-forming and antioxidant activity at the surface level, so you're getting both deeper structural support and an instant smoothing effect.There's published research behind Hexapeptide-11, showing measurable elasticity gains in just 4 weeks. It also turns on the Nrf2 pathway, your skin's built-in antioxidant defense system, and helps shield fibroblasts from the early shutdown that drives accelerated aging. Why You'll Love It Directions Full Ingredients Recycling Who is Peptides 5% best suited for, and when should I start using it? Peptides 5% is ideal if you're noticing early or established signs of ageing: fine lines, loss of firmness, reduced elasticity, or skin that's starting to feel thinner. Since collagen production drops by roughly 1% per year from your twenties, introducing peptides in your late twenties to mid-thirties is a smart preventative move, though it's equally effective on more mature skin. Its gentle, fragrance-free formula makes it a particularly good choice if your skin is too reactive for stronger anti-ageing actives like retinoids. What results can I expect from Peptides 5%, and how quickly? The lead active, Hexapeptide-11, showed measurable improvement in skin elasticity after just 4 weeks in an in vivo study on 25 volunteers. You can expect firmer, smoother-feeling skin with reduced appearance of fine lines over consistent use, while the pea peptide's film-forming action gives an immediate smoothing and moisture-retaining effect from first application. How do I use the Peptides 5% Booster? Add 1-2 drops to your moisturiser and apply as normal, morning and evening or evenings only. For targeted eye area treatment, add 1 drop to your eye cream instead. Pai's lead chemist recommends pairing it with Hyaluronic Acid 0.3% Booster for the best combination for ageing skin, covering firming, smoothing, and hydration in one routine. Is Peptides 5% suitable for sensitive skin? Yes. It's fragrance-free, essential oil-free, and non-comedogenic, so it won't clog pores or trigger irritation. Every batch undergoes 96-hour patch testing on volunteers with sensitive skin, which goes beyond standard industry requirements. It's gentle enough to use around the delicate eye area and on highly reactive skin types. Is this suitable for all skin types, including oily or combination skin? Yes. It's a lightweight, water-based formula, so it won't add heaviness or greasiness. Because you're mixing just 1-2 drops into your existing moisturiser, the texture of your routine stays exactly the same, making it easy to layer even on oily or combination skin. Can I use Peptides 5% during pregnancy or breastfeeding? Yes, Peptides 5% is confirmed safe for use during pregnancy and breastfeeding. It contains no retinoids, synthetic actives, or essential oils, making it a straightforward option for firming and smoothing support when your ingredient choices are more limited. What does the 5% concentration actually mean? The 5% is the combined total of both peptides: 0.375% Hexapeptide-11 and 4.9% pea peptide. These two actives work at very different concentrations because they have different jobs. Signal peptides like Hexapeptide-11 operate through receptor-mediated cell signalling, so they're effective at low doses. For context, Pai's Retinal Booster is just 0.16% while the Vitamin C Booster is 20%. Both concentrations here sit within the supplier-recommended ranges for optimal performance. What does Hexapeptide-11 do for my skin? Hexapeptide-11 is a yeast-fermented signal peptide that instructs your fibroblasts to ramp up collagen and elastin production. It also activates the Nrf2 pathway, your cells' master antioxidant defence system, and protects fibroblasts from premature senescence, the process where they stop building structural proteins and start secreting pro-inflammatory molecules that accelerate visible ageing. What role does the pea peptide play in this formula? Pea peptide is a 15-amino-acid chain produced through Lactobacillus fermentation at a controlled molecular weight of around 2,000 Da, making it substantially larger than the signal peptide because its job is different: supplying raw materials. It delivers all 22 amino acids, and is especially rich in lysine, the essential amino acid your body can't make on its own but needs for the hydroxylysine cross-links that give collagen fibres their structural strength (Yamauchi & Sricholpech, Biochemistry Journal, 2012). Why does the formula include prebiotic inulin? Inulin, derived from chicory root, selectively feeds beneficial skin bacteria like Lactobacillus and Bifidobacterium while inhibiting pathogens such as Staphylococcus aureus. This supports a healthy skin microbiome that reinforces your skin barrier alongside the peptide actives. It's a standard inclusion across all Pai Labs Boosters. What certifications does Peptides 5% hold? It's COSMOS Natural certified, Vegan, and Cruelty-Free with Leaping Bunny certification. The formula is 99.99% natural and free from parabens, silicones, sulfates, alcohol, fragrance, essential oils, and gluten. Pai is also a certified B Corp. How does Peptides 5% differ from Pai's Vegan Collagen and Retinoid boosters? Each targets ageing through a different mechanism. Peptides 5% stimulates your skin's own collagen and elastin production through cell signalling. Vegan Collagen 0.9% provides topical conditioning with a plant-derived collagen analogue. Retinoid 0.3% accelerates cell turnover through retinoid activity. They can be used individually or combined depending on your priority concern. What clinical evidence supports the peptides in this formula? Hexapeptide-11 is backed by peer-reviewed research (Sklirou et al., Redox Biology, 2015; PMID: 25974626). An in vivo skin deformation assay on 25 volunteers confirmed measurable improvement in skin elasticity after 4 weeks, while in vitro studies on human dermal fibroblasts showed upregulation of genes responsible for collagen, elastin precursors, and hyaluronic acid production. Pea peptide's antioxidant capacity, amino acid profile, and film-forming properties are supported by supplier data, including an ORAC study against a vitamin E analogue control. This is all ingredient-level evidence; the finished Peptides 5% formula has not undergone its own efficacy trial. What makes Peptides 5% different from other peptide serums? Most peptide serums use synthetic peptides in conventional formulations. Pai's Peptides 5% uses two naturally derived peptides, one yeast-fermented and one plant-fermented, making it one of very few peptide products that qualifies for COSMOS Natural certification. It also pairs a signal peptide (which tells your skin to produce more collagen and elastin) with a substrate peptide (which supplies the amino acid building blocks to do it), rather than relying on a single peptide type. A dual-peptide booster to firm and smooth. Walk through the peptide category and you'll see synthetics almost without exception. Ours are different: one fermented from yeast, the other from peas, both COSMOS certified. That's genuinely rare in peptide territory, which translates to real anti-aging results inside a fully natural formula. The pairing here is Hexapeptide-11 and Pea Peptide, and they handle different parts of the same job. Hexapeptide-11 acts as the messenger, telling your fibroblasts to dial up production of collagen and elastin. Pea Peptide brings the raw materials, especially lysine. It's an essential amino acid you can't produce internally, and it's vital for locking collagen molecules into resilient, well-formed fibers. The outcome: skin that feels firmer and bouncier, with a visibly smoother finish. A small piece of botany trivia: peas hold one of the most well-rounded amino acid profiles among plant proteins, containing every one of the 22 amino acids. That richness translates to film-forming and antioxidant activity at the surface level, so you're getting both deeper structural support and an instant smoothing effect. There's published research behind Hexapeptide-11, showing measurable elasticity gains in just 4 weeks. It also turns on the Nrf2 pathway, your skin's built-in antioxidant defense system, and helps shield fibroblasts from the early shutdown that drives accelerated aging. Add 1–2 drops to your moisturizer, blend in your palm, and apply as normal. That's it. Two drops pulling some serious weight. Use morning and night for the full collagen-stimulating effect, or stick with evenings only if that fits your routine better. For targeted smoothing around the eye area (yes, it's gentle enough), add a single drop to your eye cream instead. Want to go all in? Pai's lead chemist swears by Peptides + Hyaluronic Acid 0.3% as the dream duo for aging skin: firming, smoothing, and deep hydration in one step. It also pairs beautifully with Stabilized Vitamin C 20% if brightening is on your list too. Aqua (water), Pentylene Glycol, Pisum Sativum Peptide (pea), Glycerin, Xanthan Gum, Cellulose, Hexapeptide-11, Leuconostoc/radish Root Ferment Filtrate, Sodium Hydroxide, Sodium Phytate, Glyceryl Caprylate, Tocopherol* (vitamin e). 99.99% natural origin. *Organic Say no to landfill! Let's recycle everything! - Sarah Unscrew the dropper and remove it from the bottle. Gently pull the glass pipette out of the dropper. Rinse the glass bottle and pipette, then place them in your curbside recycling. The dropper and rubber bulb are not curbside recyclable. All Pai boxes, cartons, sleeves and inserts can be recycled with your curbside paper recycling. Some product components are not currently curbside recyclable in most US programs. We are working on a US-specific recycling solution. In the meantime, check what your local recycling provider accepts at earth911.com . We use cookies to make the Pai website work properly, remember your preferences, and understand how people use the site so we can improve it. We also use cookies to measure our advertising so we can spend wisely and keep our prices fair. Allowing all cookies helps us keep the site running smoothly and reach more people who might benefit from our products. Privacy Policy Key Ingredients Peptides If plump, bouncy, youthful skin is your goal, this one’s for you. Peptides are clever amino acids best known for stimulating collagen and elastin - meaning fewer lines and firmer skin. Ours is all-natural: yeast-derived Hexapeptide joins the humble yet hardworking Pea Peptide, rich in lysine to support healthy skin. 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